Key result
Traditional Chinese Medicine improves ejection fraction and metabolic parameters in diabetic cardiomyopathy animal models.
Why the study?
The efficacy of Traditional Chinese Medicine in animal models of diabetic cardiomyopathy had not been systematically analyzed.
Does Traditional Chinese Medicine improve metabolic and cardiac function parameters in animal models of diabetic cardiomyopathy?
Meta-Analysis (n=2,157)
Does Traditional Chinese Medicine improve metabolic and cardiac function parameters in animal models of diabetic cardiomyopathy?
Effect estimate: SMD 2.79 (95% CI 2.39-3.20)
p-value: p=<0.00001
Traditional Chinese Medicine interventions significantly improve metabolic and echocardiographic parameters in animal models of diabetic cardiomyopathy.
Supports TCM evaluation in diabetic cardiomyopathy models; leaves open human translation pending prospective trials.
Background: Diabetic cardiomyopathy (DCM) is a severe complication of diabetes that can diminish the quality of life in patients and is a leading cause of death. Research has demonstrated the effectiveness of Traditional Chinese Medicine (TCM) in reducing blood sugar levels and protecting cardiovascular function in both animal models and clinical research studies. Nevertheless, the efficacy of TCM in animal models of DCM has not been analyzed systematically. Method: We searched the following electronic bibliographic databases: Web of Science, PubMed, Cochrane Library, and CNKI(China National Knowledge Infrastructure). Studies that reported the efficacy of TCM in animals with DCM were included. The literature search was conducted using the terms. The data will be restricted from the year 2013 to 24 April 2023, 24 studies were included in the meta-analysis. Result: A total of 24 Traditional Chinese Medicine interventions and 2157 animals met the inclusion criteria. The pooled data revealed that TCM interventions resulted in significant improvements in body weight (BW), heart weight (HW) to body weight ratio (HW/BW), triglyceride (TG) and cholesterol (TC) levels, ejection fraction (EF), fractional shortening (FS) and E/A ratio. Subgroup analysis and meta-regression revealed that the type of TCM, duration of intervention, method of modeling, and animal species were potential sources of heterogeneity. Conclusion: TCM interventions were associated with significant improvements in body weight, heart weight to body weight ratio, triglyceride and cholesterol levels, left ventricular internal dimension in systole, ejection fraction, fractional shortening and E/A ratio. The heterogeneity in the results was found to be potentially due to the type of TCM, duration of intervention, method of modeling, and animal species, as shown in subgroup analysis and meta-regression. Systematic Review Registration: identifier CRD42023402908
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Hu et al. (2023) conducted a meta-analysis in Diabetic cardiomyopathy (n=2,157). Traditional Chinese Medicine (TCM) vs. Vehicle, saline, or water control was evaluated on Ejection fraction (SMD 2.79, 95% CI 2.39-3.20, p=<0.00001). Traditional Chinese Medicine interventions significantly improved ejection fraction (SMD 2.79) and other cardiac and metabolic parameters compared to control in animal models of diabetic cardiomyopathy.
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