Key result
IL-3 induces increased translation of a subset of mRNAs, and Pin1 controls mRNA binding protein activity to enhance mRNA stability, GM-CSF production, and prolonged eosinophil survival.
This review highlights the role of IL-3 signaling and mRNA binding proteins in regulating protein translation in human eosinophils, identifying potential therapeutic targets for eosinophil-associated diseases.
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Hypothesis-generating for IL-3/Pin1-targeted therapies in eosinophil diseases; prospective trials needed before clinical adoption.
We have recently reported that, unlike IL-5 and GM-CSF, IL-3 induces increased translation of a subset of mRNAs. In addition, we have demonstrated that Pin1 controls the activity of mRNA binding proteins, leading to enhanced mRNA stability, GM-CSF protein production and prolonged eosinophil (EOS) survival. In this review, discussion will include an overview of cap-dependent protein translation and its regulation by intracellular signaling pathways. We will address the more general process of mRNA post-transcriptional regulation, especially regarding mRNA binding proteins, which are critical effectors of protein translation. Furthermore, we will focus on (1) the roles of IL-3-driven sustained signaling on enhanced protein translation in EOS, (2) the mechanisms regulating mRNA binding proteins activity in EOS, and (3) the potential targeting of IL-3 signaling and the signaling leading to mRNA binding activity changes to identify therapeutic targets to treat EOS-associated diseases.
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Esnault et al. (2017) conducted a review in Eosinophil biology. IL-3 induces increased translation of a subset of mRNAs, and Pin1 controls mRNA binding protein activity to enhance mRNA stability, GM-CSF production, and prolonged eosinophil survival.
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