What question did this study set out to answer?

To synthesize current scientific evidence regarding novel genetic, epigenetic, proteomic, and metabolomic biomarkers for the early detection of gastric cancer and assess their clinical utility.

October 31, 2025Frontiers in PharmacologyOpen Access

Potential biomarkers in early detection of gastric cancer

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Authors

SKSupreet KaurIndian Institute of Science Education and Research Mohali AKAnkush KumarAmity University RBRohit BhatiaChitkara University

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Implication

Review uncovers novel diagnostic biomarkers in gastric cancer, indicating potential strategies to improve early detection and reduce global mortality.

Key Points

To synthesize current scientific evidence regarding novel genetic, epigenetic, proteomic, and metabolomic biomarkers for the early detection of gastric cancer and assess their clinical utility.
Reviewed literature evaluating genomic and molecular signatures implicated in early-stage gastric cancer detection.
Examined mechanistic roles and clinical applicability across metabolic, genetic, epigenetic, and protein-based diagnostic markers.
Identified prominent candidate protein biomarkers, including HSPA6, ANXA11, CDC42, FAP, HAMP, SLC25A4, SERPINH1, cystatin B, DMBT1, and PRTN3.
Detailed the diagnostic roles of key non-coding RNA markers, specifically NEAT1, circular RNAs, and N6-methyladenosine-related lncRNAs.
Highlighted that applying these molecular signatures to early-stage screening could lower gastric cancer mortality and improve patient quality of life.

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/6a184a028dad9275931ea290 https://doi.org/10.3389/fphar.2025.1642927

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Implication

Review uncovers novel diagnostic biomarkers in gastric cancer, indicating potential strategies to improve early detection and reduce global mortality.

Potential biomarkers in early detection of gastric cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Potential biomarkers in early detection of gastric cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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