Key result
ART nonuse and multi-core regimens are linked to increased incident AF risk in HIV.
Why the study?
To assess risk factors for atrial fibrillation in people with HIV.
Does the nonuse of antiretroviral therapy or the use of specific antiretroviral regimens increase the risk of incident atrial fibrillation in people with HIV?
Case-Control (n=1,067)
Yes
Does the nonuse of antiretroviral therapy or the use of specific antiretroviral regimens increase the risk of incident atrial fibrillation in people with HIV?
In people with HIV, nonuse of antiretroviral therapy and the use of regimens with multiple core agents are associated with an increased risk of developing incident atrial fibrillation.
Does not support changing ART practices in HIV; hypothesis-generating for AF risk and requires prospective validation.
To assess atrial fibrillation risk factors in people with HIV, we identified incident atrial fibrillation in a large clinical cohort of people receiving care. Compared with 970 controls without atrial fibrillation, the 97 with adjudicated incident atrial fibrillation were older, less likely Hispanic, and had more coronary disease, heart failure, and chronic obstructive pulmonary disease. In multivariable analysis, nonuse of antiretroviral therapy and prescription of antiretroviral regimens with multiple core agents were associated with increased atrial fibrillation risk.
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Nance et al. (2022) conducted a case-control in Atrial fibrillation in people with HIV (n=1,067). Nonuse of antiretroviral therapy or multi-core ART regimens vs. Standard antiretroviral therapy use was evaluated on Incident atrial fibrillation. In people with HIV, nonuse of antiretroviral therapy and prescription of multi-core antiretroviral regimens were associated with an increased risk of incident atrial fibrillation.
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