Why the study?
What patient characteristics and drug regimens are associated with fatal adverse drug events in medical inpatients?
Population
732 patients dying in a department of internal medicine at a Norwegian county hospital over a 2-year period
Comparison
Various drug regimens vs Non-FADE cases
Design
Cohort
Follow-up
2 years
Authors
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FADEs linked to polypharmacy and age in dying inpatients; hypothesis-generating for prevention trials, not yet practice-changing.
What patient characteristics and drug regimens are associated with fatal adverse drug events in medical inpatients?
Fatal adverse drug events occurred in 18.2% of dying medical inpatients, strongly associated with polypharmacy, older age, and specific drug classes including cardiovascular medications.
Buajordet et al. (2001) studied this question.
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