Factors affecting the sex ratio in large populations

Summary and conclusions To summarize the findings presented here, only three of the five factors studied appear to be independently related to the sex ratio at birth. The significant negative birth-order effect, which in the first analysis accounted for a 2·6% shift in the relative odds of male birth, remained significant when adjustment for the race effect was provided in the second analysis. The magnitude of the effect was diminished by this adjustment, however, indicating that analysis for birth-order effects in the absence of adjustment for the race factor may lead to over-estimates of the importance of the birth-order factor. The significant race effect detected in the second analysis resulted in a 3% lower relative odds for a Negro male birth than that for a white. This racial difference, coupled with the non-uniform distribution of Negro births by paternal-age and birth-order categories, appears to be the source of the mysterious ‘interaction effect’ between birth order and paternal age reported by Novitski & Kimball. The race effect remained significant after adjustment was provided for both the birthorder and socio-economic effects.