Low DOAC plasma levels on admission independently predicted large vessel occlusion (OR 3.84; 95% CI 1.80-8.20; P=0.001) and were associated with higher stroke severity.
Observational (n=460)
Do higher DOAC plasma levels reduce stroke severity and the risk of large vessel occlusion in patients with atrial fibrillation admitted with acute cerebral ischemia?
In patients with atrial fibrillation experiencing acute cerebral ischemia, low DOAC plasma levels on admission are associated with greater stroke severity and a significantly higher risk of large vessel occlusion.
Estimación del efecto: OR 3.84 (95% CI 1.80-8.20)
valor p: p=0.001
Background and Purpose- In patients with ischemic stroke on therapy with vitamin K antagonists, stroke severity and clinical course are affected by the quality of anticoagulation at the time of stroke onset, but clinical data for patients using direct oral anticoagulants (DOACs) are limited. Methods- Data from our registry including all patients admitted with acute cerebral ischemia while taking oral anticoagulants for atrial fibrillation between November 2014 and October 2017 were investigated. The activity of vitamin K antagonists was assessed using the international normalized ratio on admission and categorized according to a threshold of 1.7. DOAC plasma levels were measured using the calibrated Xa-activity (apixaban, rivaroxaban, and edoxaban) or the Hemoclot-assay (dabigatran) and categorized into low (100 ng/mL). Primary objective was the association between anticoagulant activity and clinical and imaging characteristics. Results- Four hundred sixty patients were included (49% on vitamin K antagonists and 51% on DOAC). Patients on vitamin K antagonists with low international normalized ratio values had higher scores on the National Institutes of Health Stroke Scale and a higher risk of large vessel occlusion on admission. For patients on DOAC, plasma levels were available in 75.6% and found to be low in 49 (27.7%), intermediate in 41 (23.2%), and high in 87 patients (49.2%). Low plasma levels were associated with higher National Institutes of Health Stroke Scale scores on admission (low: 8 interquartile range, 3-15 versus intermediate: 4 1-11 versus high: 3 0-8; P<0.001) and higher risk of persisting neurological deficits or cerebral infarction on imaging (85.7% versus 75.6% versus 54.0%; P<0.001). Low DOAC plasma levels were an independent predictor of large vessel occlusion (odds ratio, 3.84 95% CI, 1.80-8.20; P=0.001). Conclusions- The activity of anticoagulation measured by specific DOAC plasma levels on admission is associated with stroke severity and presence of large vessel occlusion.
Macha et al. (Mon,) conducted a observational in Acute cerebral ischemia and atrial fibrillation (n=460). Direct oral anticoagulants (DOACs) vs. Vitamin K antagonists was evaluated on Large vessel occlusion (OR 3.84, 95% CI 1.80-8.20, p=0.001). Low DOAC plasma levels on admission independently predicted large vessel occlusion (OR 3.84; 95% CI 1.80-8.20; P=0.001) and were associated with higher stroke severity.
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