Why the study?
In acute stroke patients, DOAC plasma concentrations at admission poorly mirror exposure or coagulation status at event onset, and their correlation with event occurrence was unclear.
Is low DOAC exposure associated with an increased likelihood and severity of ischemic stroke in patients taking DOACs?
Is low DOAC exposure associated with an increased likelihood and severity of ischemic stroke in patients taking DOACs?
Low DOAC exposure, often related to receiving lower than recommended doses, is strongly associated with the occurrence and severity of ischemic strokes.
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Low DOAC exposure was associated with worse ischemic events; hypothesis-generating finding leaves open need for prospective dosing trials.
Rizos et al. (2022) studied this question.
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