Inhibitors of Tyrosine Kinases Involved in Inflammation and Autoimmune Disease

The study of tyrosine kinases involved in cellular signaling associated with inflammation and autoimmune disease is rapidly progressing. Lessons learned from recent successes in identifying novel, potent, and selective tyrosine kinase inhibitors for the treatment of cancer and cardiovascular disease can be applied toward developing selective tyrosine kinase inhibitors for targets associated with diseases such as rheumatoid arthritis, sepsis and autoimmune disease. The design of new selective tyrosine kinase inhibitors will be aided by the very recent successes in solving X-ray crystal structures of the catalytic domains of several kinases. This paper summarizes the literature on inhibitors of several non- receptor and receptor tyrosine kinases thought to be involved in cellular signaling associated with infl_ammatory diseases.