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This research aims to determine how hematologic variables, notably leukocyte count, affect thrombotic risk in patients with polycythemia vera.

November 14, 2006BloodOpen Access

Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera

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This research aims to determine how hematologic variables, notably leukocyte count, affect thrombotic risk in patients with polycythemia vera.
Analyzed data from 1638 polycythemic patients followed for an average of 2.7 years.
Investigated the association between leukocyte counts, cardiovascular risk factors, and thrombotic events.
Conducted time-dependent analysis adjusted for potential confounders.
Patients with leukocyte counts above 15 x 10(9)/L had a significant increase in thrombosis risk (HR, 1.71; 95% CI, 1.10-2.65; P = .017).
The risk of myocardial infarction was notably higher in this group (HR, 2.84; 95% CI, 1.25-6.46; P = .013).
Smoking was associated with an increased risk of arterial thrombosis (HR, 1.90; 95% CI, 1.15-3.14; P = .012).

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Observational study reveals leukocyte count predicts thrombotic risk in polycythemia vera patients, suggesting new assessment criteria.

Landolfi et al. (2006) studied this question.

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