Key result
Ischemic conditioning, delivered locally or remotely via brief repetitive cycles of ischemia, recruits signaling pathways that may provide cardioprotection against reperfusion injury.
Why the study?
Does ischemic conditioning provide cardioprotection against reperfusion injury?
Does ischemic conditioning provide cardioprotection against reperfusion injury?
This review provides an overview of the molecular mechanisms underlying ischemic conditioning and evaluates its potential translation into clinical practice for cardioprotection.
Does not support clinical adoption of ischemic conditioning; leaves open translation pending randomized trials.
Following the initiation of an ischemic insult, reperfusion injury (RI) can result in numerous deleterious cardiac effects, including cardiomyocyte death. Experimental data have suggested that ischemic conditioning, when delivered either before or after the ischemic event, can provide considerable cardioprotection against RI. Ischemic conditioning involves delivering brief repetitive cycles of ischemia to the myocardium (local) or to another distal organ or structure (remote). This review will discuss recent advances in the molecular mechanisms involved in RI, the signaling pathways recruited by ischemic conditioning and conclude with an appraisal of the evidence for the use of ischemic conditioning in current clinical practice.
No takes yet. Share an insight, caveat, or question.
Brooks et al. (2013) conducted a review in Reperfusion injury. Ischemic conditioning was evaluated. Ischemic conditioning, delivered locally or remotely via brief repetitive cycles of ischemia, recruits signaling pathways that may provide cardioprotection against reperfusion injury.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: