Key result
Early botulinum toxin A within 90 days of stroke is linked to greater spasticity reduction.
Why the study?
Does early botulinum toxin type A injection improve muscle tone and motor recovery in post-stroke patients with spasticity compared to later treatment?
Population
Post-stroke patients with spasticity who are naïve to botulinum toxin treatment.
Comparison
Early botulinum toxin type A injection combined… vs Later botulinum toxin type A injection combined…
Design
Cohort, open-label
Follow-up
24 weeks post-injection
Authors
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Early administration of botulinum toxin type A (within 90 days of stroke) for post-stroke spasticity enhances spasticity reduction and motor recovery compared to delayed treatment.
Cohort
Open-label
Yes
Does early botulinum toxin type A injection improve muscle tone and motor recovery in post-stroke patients with spasticity compared to later treatment?
Early administration of botulinum toxin type A (within 90 days of stroke) for post-stroke spasticity enhances spasticity reduction and motor recovery compared to delayed treatment.
Picelli et al. (2025) conducted a cohort in Post-stroke spasticity. Early botulinum toxin type A injection (within 90 days of stroke onset) vs. Later treatment was evaluated on Muscle tone. Early botulinum toxin type A injection within 90 days of stroke onset was associated with greater reductions in spasticity and improved motor recovery compared with later treatment.