What question did this study set out to answer?

To review the current state of knowledge regarding high-throughput omics technologies and their role in elucidating the pathogenesis and etiology of achalasia.

September 21, 2024International Journal of Molecular SciencesOpen Access

Focus on Achalasia in the Omics Era

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Authors

ABAnna Laura Pia Di BrinaCasa Sollievo della Sofferenza OPOrazio PalmieriCasa Sollievo della Sofferenza ACAnna Lucia CannarozziCasa Sollievo della Sofferenza

Discussion

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Implication

Narrative review uncovers omics-based molecular mechanisms of achalasia, suggesting multi-omics integration improves early diagnosis and patient management.

Key Points

To review the current state of knowledge regarding high-throughput omics technologies and their role in elucidating the pathogenesis and etiology of achalasia.
Narrative review of published literature on DNA, RNA, and biomolecular high-throughput analyses in achalasia.
Evaluation of single-omics and multi-omics data integration, study limitations, and prospective clinical utilities.
High-throughput molecular techniques identify genomic, transcriptomic, and biomolecular alterations linked to impaired lower esophageal sphincter relaxation and absent peristalsis.
Multi-omics integration overcomes single-dataset limitations to clarify disease etiology and provides molecular markers for earlier diagnosis and targeted management.

Cite This Study

Brina et al. (2024) studied this question.

synapsesocial.com/papers/6a1890413ad5dee7381ef452 https://doi.org/10.3390/ijms251810148

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Implication

Narrative review uncovers omics-based molecular mechanisms of achalasia, suggesting multi-omics integration improves early diagnosis and patient management.

Focus on Achalasia in the Omics Era

Discussion

Member takes

Implication

Key Points

Cite This Study

Focus on Achalasia in the Omics Era

Discussion

Member takes

Implication

Key Points

Cite This Study

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