What question did this study set out to answer?

To evaluate the clinical importance and prognostic value of circumferential resection margin (CRM) involvement in the modern era of multimodal rectal cancer treatment.

January 8, 2008Journal of Clinical Oncology

What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer?

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Authors

INIrıs D. Nagtegaal PQPhilip Quirke

Discussion

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Overview

Review reveals circumferential resection margin involvement predicts recurrence and poor survival in rectal cancer, highlighting its critical role in guiding post-operative care.

Key Points

To evaluate the clinical importance and prognostic value of circumferential resection margin (CRM) involvement in the modern era of multimodal rectal cancer treatment.
Reviewed clinical evidence evaluating circumferential resection margin involvement across a combined cohort of more than 17,500 patients.
Assessed outcomes in the context of total mesorectal excision and preoperative radiotherapy or radiochemotherapy.
CRM involvement predicted local recurrence significantly more strongly following neoadjuvant radio(chemo)therapy compared to surgery without preoperative therapy (HR = 6.3 vs 2.0; P < .05).
CRM involvement strongly predicted the development of distant metastases (HR = 2.8; 95% CI, 1.9 to 4.3).
Involvement of the CRM was significantly associated with reduced overall survival (HR = 1.7; 95% CI, 1.3 to 2.3).

Cite This Study

Nagtegaal et al. (2008) studied this question.

synapsesocial.com/papers/6a189332985da83d549181ef https://doi.org/10.1200/jco.2007.12.7027

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January 8, 2008Journal of Clinical Oncology

What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer?

View Full Paper

Ask AI

Bookmark

Authors

INIrıs D. Nagtegaal PQPhilip Quirke

Discussion

Member takes

Overview

Review reveals circumferential resection margin involvement predicts recurrence and poor survival in rectal cancer, highlighting its critical role in guiding post-operative care.

Key Points

To evaluate the clinical importance and prognostic value of circumferential resection margin (CRM) involvement in the modern era of multimodal rectal cancer treatment.
Reviewed clinical evidence evaluating circumferential resection margin involvement across a combined cohort of more than 17,500 patients.
Assessed outcomes in the context of total mesorectal excision and preoperative radiotherapy or radiochemotherapy.
CRM involvement predicted local recurrence significantly more strongly following neoadjuvant radio(chemo)therapy compared to surgery without preoperative therapy (HR = 6.3 vs 2.0; P < .05).
CRM involvement strongly predicted the development of distant metastases (HR = 2.8; 95% CI, 1.9 to 4.3).
Involvement of the CRM was significantly associated with reduced overall survival (HR = 1.7; 95% CI, 1.3 to 2.3).

Cite This Study

Nagtegaal et al. (2008) studied this question.

synapsesocial.com/papers/6a189332985da83d549181ef https://doi.org/10.1200/jco.2007.12.7027

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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