Key result
Patients with primary Raynaud's phenomenon exhibited significantly reduced time-domain heart rate variability, including a lower SDNN index (55.71 vs 82.03), indicating autonomic imbalance.
Why the study?
Do patients with primary Raynaud's phenomenon have altered time-domain heart rate variability indices compared to healthy controls?
Case-Control (n=61)
No
Do patients with primary Raynaud's phenomenon have altered time-domain heart rate variability indices compared to healthy controls?
Absolute Event Rate: 55.71% vs 82.03%
p-value: p=0.001
Patients with primary Raynaud's phenomenon exhibit decreased time-domain heart rate variability, indicating an autonomic imbalance characterized by increased sympathetic and decreased parasympathetic activity.
Reduced HRV indicates autonomic imbalance in primary Raynaud's; hypothesis-generating and should not yet change practice.
OBJECTIVES: The pathogenesis of primary Raynaud's phenomenon (RP) seems to be multifactorial and autonomic nervous dysfunction is one factor. Heart rate variability (HRV) is one of the most reliable parameters to demonstrate autonomic dysfunction. Our aim was to evaluate the time-domain HRV in patients with primary RP. METHODS: A time analysis of HRV was performed in patients with primary RP and age- and gender-matched healthy controls. The results of the study and control group were compared. RESULTS: Thirty patients with primary RP [all men, median (IQR) age: 21 (2) years) and 31 age- and gender-matched healthy controls (median (IQR): 21(3) years] were enrolled in the study. We found a statistically significant difference between the primary RP patients and control subjects in terms of time-domain HRV parameters (p < 0.05 for all). CONCLUSION: Our study showed the presence of autonomic nervous dysfunction of heart function in patients with primary RP.
No takes yet. Share an insight, caveat, or question.
Karabacak et al. (2015) conducted a case-control in Primary Raynaud's phenomenon (n=61). Primary Raynaud's phenomenon (Exposure) vs. Healthy controls was evaluated on SDNN index (ms) (p=0.001). Patients with primary Raynaud's phenomenon exhibited significantly reduced time-domain heart rate variability, including a lower SDNN index (55.71 vs 82.03), indicating autonomic imbalance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: