Key result
Genotypic variants in the angiotensin II, PPAR-gamma, and adrenergic systems occur at different frequencies in African Americans, potentially explaining racial differences in cardiovascular disease.
Recognition of genotypic differences in cardiovascular regulatory systems between African Americans and Americans of European descent may enable the development of tailored, individualized therapies.
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May support genotype-guided therapy development in African Americans; hypothesis-generating and should not yet change practice.
Gary H. Gibbons (2004) conducted a review in Cardiovascular disease. Genotypic variants in the angiotensin II, PPAR-gamma, and adrenergic systems occur at different frequencies in African Americans, potentially explaining racial differences in cardiovascular disease.
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