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June 27, 1994FEBS Letters

Activation of human peripheral monocytes by angiotensin II

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Why the study?

Does angiotensin II activate human peripheral blood monocytes?

Population

Human peripheral blood monocytes and monolayers of human endothelial cells

Design

Preclinical

Authors

AHAlfred W.A. HahnUniversity Hospital of BaselUJU. JonasUniversity of FreiburgFBFritz R. BühlerGeneral / Preventive / Lipids

Discussion

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Implication

May implicate Ang II-AT1 signaling in monocyte activation; leaves open translation to human atherogenesis.

Structured PICO

Does angiotensin II activate human peripheral blood monocytes?

P
Population
Human peripheral blood monocytes and monolayers of human endothelial cells
I
Intervention
Angiotensin II
O
Outcome
Activation of monocytes (measured by release of tumor necrosis factor alpha and adhesion to endothelial cells)surrogate

Angiotensin II directly activates human peripheral monocytes via the AT1 receptor, suggesting a mechanism for monocyte infiltration in atherogenesis and hypertension.

Cite This Study

Hahn et al. (1994) studied this question.

synapsesocial.com/papers/6a1db85b984ea5c2d0ce3231https://doi.org/10.1016/0014-5793(94)00531-1
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