Population
Human peripheral blood monocytes (HPBM) and human THP-1 monocytes
Comparison
Angiotensin II (0.01 to 1 micromol/L) vs Unstimulated cells
Design
Preclinical
Authors
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Supports Ang II role in human monocyte recruitment to plaques; leaves open whether AT1-R blockade alters clinical atherogenesis.
Angiotensin II promotes atherogenesis by stimulating human monocyte migration through an AT1-R-dependent process involving Src, ERK 1/2, p38, and phosphorylation of Pyk2 and paxillin.
Kintscher et al. (2001) studied this question.
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