Key result
Angiotensin II increases matrix metalloproteinase-1 production in cytokine-stimulated human monocytes via the AT2 receptor and prostaglandin E2.
Population
Human primary monocytes
Design
Preclinical
Authors
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May link Ang II to monocyte-driven plaque instability in hypertension; leaves open AT2/PGE2 pathway for targeted validation.
Angiotensin II increases MMP-1 production in human monocytes via the AT2 receptor and PGE2, providing a potential mechanism for atherosclerotic plaque rupture in hypertension.
Kim et al. (2005) studied Atherosclerotic plaque rupture. Angiotensin II was evaluated on Matrix metalloproteinase-1 (MMP-1) production. Angiotensin II increases matrix metalloproteinase-1 production in cytokine-stimulated human monocytes via the AT2 receptor and prostaglandin E2.
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