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January 1, 2007Perfusion

Effect of angiotensin II on primary cardiac fibroblast matrix metalloproteinase activities

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Population

Primary adult murine cardiac fibroblasts (CF)

Comparison

Angiotensin II with and without AT1-R blocker or… vs Angiotensin II only group

Design

Preclinical

Follow-up

48 hours

Authors

LSLaura Buford StacyQYQianli YuKHKatherine Horak

Discussion

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Overview

Differential MMP modulation by Ang II and ARBs may affect fibroblast remodeling; leaves open clinical translation from this animal model.

Structured PICO

P
Population
Primary adult murine cardiac fibroblasts (CF)
I
Intervention
Angiotensin II (10^-6 M) with and without AT1-R blocker (losartan) or AT2-R blocker (PD123319) at doses of 10^-7 to 10^-5 M for 48 hours
C
Comparator
Angiotensin II only group
O
Outcome
Enzymatic activities of matrix metalloproteinases (collagenase, MMP-2, and MMP-9 gelatinase activities)surrogate

Angiotensin II and its selective receptor blockers differentially modulate matrix metalloproteinase activities in cardiac fibroblasts, which may influence extracellular matrix remodeling.

Cite This Study

Stacy et al. (2007) studied this question.

synapsesocial.com/papers/6a79ed321ba4614d7ff3b631https://doi.org/10.1177/0267659106074793
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Type 2 Receptor Is Upregulated in Human Heart With Interstitial Fibrosis, and Cardiac Fibroblasts Are the Major Cell Type for Its Expression1998 · 241 citations
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  3. 3The renin-angiotensin-aldosterone system and myocardial collagen matrix remodelling in congestive heart failure1995 · 107 citations
  4. 4Angiotensin II Type 2 Receptor Is Essential for Left Ventricular Hypertrophy and Cardiac Fibrosis in Chronic Angiotensin II–Induced Hypertension2001 · 300 citations
  5. 5Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases1998 · 479 citations