Key result
Prior intensive diabetes treatment was associated with significantly lower geometric mean CAC scores and a lower prevalence of CAC >200 compared with conventional treatment.
Why the study?
Does intensive glycemic treatment reduce coronary artery calcification in patients with type 1 diabetes?
Population
1,205 patients with type 1 diabetes from the DCCT/EDIC cohort
Comparison
Intensive diabetes treatment for 6.5 years… vs Conventional diabetes treatment during the DCCT
Design
Cohort
Follow-up
7-9 years after the end of the DCCT
Authors
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May indicate legacy benefit of intensive therapy on CAC in type 1 diabetes; extends DCCT but leaves causal effects open.
Cohort (n=1,205)
Does intensive glycemic treatment reduce coronary artery calcification in patients with type 1 diabetes?
Intensive glycemic control in type 1 diabetes is associated with reduced long-term coronary artery calcification, driven primarily by lower HbA1c levels.
Cleary et al. (2006) conducted a cohort in Type 1 diabetes (n=1,205). Intensive diabetes treatment vs. Conventional diabetes treatment was evaluated on Coronary artery calcification (CAC) >0 and >200 Agatston units. Prior intensive diabetes treatment was associated with significantly lower geometric mean CAC scores and a lower prevalence of CAC >200 compared with conventional treatment.
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