Key result
Pediatric LVNC links to frequent ECG abnormalities, featuring left ventricular-derived defects in ~40% of cases.
Why the study?
LVNC is associated with arrhythmias and sudden cardiac death, but systematic review of reported ECG results in pediatric patients was needed to characterize electrophysiological patterns.
Systematic Review (n=57)
Pediatric LVNC is associated with a broad spectrum of ECG abnormalities, notably left ventricular hypertrophy, ventricular arrhythmias, and Wolff-Parkinson-White patterns, highlighting the need for careful electrophysiological evaluation and risk stratification.
Requires ECG surveillance in pediatric LVNC; extends observational data to quantify arrhythmia burden for stratification.
Left ventricular noncompaction cardiomyopathy (LVNC) is a structural heart defect that has been associated with generation of arrhythmias in the population and is a cause of sudden cardiac death with severe systolic dysfunction and fatal arrhythmias. LVNC has gained increasing acknowledgment with increased prevalence. We conducted a systematic review of reported electrocardiogram (ECG) results for pediatric LVNC patients. EMBASE database query was performed, yielding 4531 articles related to LVNC between 1990 and December 2023. Patient age ranged from prenatal to 18 years of age. Qualitative analyses were performed to characterize individual arrhythmias, and summative interpretation of ECG evaluations was gathered for the entire cohort. Systematic review of 57 LVNC cases and ECG presentation revealed many waveform consistencies, including abnormal left ventricular, atrioventricular node, and interventricular septal patterns, and specifically a high incidence of Mobitz type II and Wolff–Parkinson–White waveforms. This review of ECG analysis reinforces the clinical and etiologic significance of pediatric LVNC. While LVNC in pediatric populations may not always present as acute clinical cases, further investigation into the electrophysiology of the disease supports the need for further evaluation and risk stratification for patients with suspected LVNC and/or ventricular arrhythmia.
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Fitzsimons et al. (2024) conducted a systematic review in Left ventricular noncompaction cardiomyopathy (LVNC) (n=57). Left ventricular noncompaction cardiomyopathy (LVNC) was evaluated on Electrocardiogram (ECG) abnormalities. Pediatric patients with left ventricular noncompaction cardiomyopathy frequently exhibit ECG abnormalities, including left ventricular-derived defects in 40% of cases, ventricular arrhythmias in 21%, and Wolff-Parkinson-White patterns in 9%.
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