Key result
Surgical resection remains the mainstay of curative treatment for lipomatous tumors, while large, high-grade liposarcomas may benefit from multimodality treatment with chemotherapy and radiation.
Surgical resection remains the primary treatment for lipomatous tumors, with multimodality therapy reserved for large, high-grade liposarcomas.
Supports resection-first strategy for lipomatous tumors; leaves open prospective trials on multimodality therapy for high-grade cases.
Lipomatous tumors range from benign lipomas to high-grade liposarcomas. Liposarcomas are classified into five histologic subtypes: well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic, which differ in outcomes and patterns of recurrence. Surgical resection is the mainstay of curative treatment; however, large, high grade liposarcomas may benefit from multimodality treatment with chemotherapy and radiation. A histologic-subtype specific nomogram provides accurate survival predictions. Prospective randomized clinical trials will continue to improve our care of patients with liposarcoma.
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Dalal et al. (2008) conducted a review in Lipomatous tumors. Surgical resection and multimodality treatment was evaluated. Surgical resection remains the mainstay of curative treatment for lipomatous tumors, while large, high-grade liposarcomas may benefit from multimodality treatment with chemotherapy and radiation.
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