Key result
Zebrafish serve as an emerging vertebrate model to study the molecular mechanisms of cardiac sarcomere assembly and the pathogenesis of sarcomere-based cardiac diseases.
Zebrafish serve as a valuable emerging vertebrate model for elucidating the molecular mechanisms of sarcomere assembly and the pathogenesis of sarcomere-based cardiac diseases like hypertrophic cardiomyopathy.
Supports zebrafish models for sarcomere research; leaves open translation to human cardiomyopathies.
Mutations in sarcomere genes have been found in many inheritable human diseases, including hypertrophic cardiomyopathy. Elucidating the molecular mechanisms of sarcomere assembly shall facilitate understanding of the pathogenesis of sarcomere-based cardiac disease. Recently, biochemical and genomic studies have identified many new genes encoding proteins that localize to the sarcomere. However, their precise functions in sarcomere assembly and sarcomere-based cardiac disease are unknown. Here, we review zebrafish as an emerging vertebrate model for these studies. We summarize the techniques offered by this animal model to manipulate genes of interest, annotate gene expression, and describe the resulting phenotypes. We survey the sarcomere genes that have been investigated in zebrafish and discuss the potential of applying this in vivo model for larger-scale genetic studies.
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Yang et al. (2014) conducted a review in Sarcomere-based cardiac disease. Zebrafish model was evaluated. Zebrafish serve as an emerging vertebrate model to study the molecular mechanisms of cardiac sarcomere assembly and the pathogenesis of sarcomere-based cardiac diseases.
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