Continuous social jetlag in adolescents was negatively correlated with gut microbial α-diversity at the family level (r=-0.183) and associated with shifts in functionally relevant gut taxa.
Cross-Sectional (n=120)
No
Is social jetlag associated with changes in gut microbiome profiles in healthy adolescents?
Social jetlag in adolescents is associated with shifts in functionally relevant gut taxa rather than global ecological restructuring.
Effect estimate: r -0.183
p-value: p=0.048
Background: The microbiota-gut-brain axis plays a vital role in health, with growing evidence linking SJL to the gut microbiome. In this study, the relationship between self-reported SJL and gut microbiome composition is evaluated in an adolescent population. Methods: A total of 120 healthy adolescents (69 females, 51 males; mean age 12. 69± 0. 65 years) were included. We investigated the associations of self-reported SJL with gut microbial α-diversity, the Firmicutes/Bacteroidetes (F/B) ratio, specific bacterial taxa, and functional gene diversity. Results: Participants had an average SJL of 0. 87± 0. 73 h, with 25. 0% experiencing SJL ≥ 2 h/d. Although continuous SJL was negatively correlated with α-diversity at the family level (Shannon and Simpson indices, all P < 0. 05), no significant differences were found between the SJL < 2 and ≥ 2 h/d groups. Several taxa across multiple taxonomic levels (e. g. Bacteroidia and Bacteroidales) were associated with SJL (P < 0. 05). Differential abundance was observed for multiple families and genera between these two SJL groups. After FDR correction (q ≤ 0. 05), only the glutamate dehydrogenase gene gdhK00262 was significantly enriched in the high SJL group (q =0. 05). Conclusion: SJL is associated with shifts in functionally relevant gut taxa, rather than a global ecological restructuring, in adolescents. Future work is needed to decipher the mechanisms of this microbiome-SJL interaction and its health significance. Keywords: gut microbiome, sleep jetlag, adolescents
Gong et al. (Fri,) conducted a cross-sectional in Social Jetlag (n=120). High Social Jetlag (≥2 hours/day) vs. Low Social Jetlag (<2 hours/day) was evaluated on Gut microbial α-diversity (Shannon index at family level) correlation with continuous social jetlag (r -0.183, p=0.048). Continuous social jetlag in adolescents was negatively correlated with gut microbial α-diversity at the family level (r=-0.183) and associated with shifts in functionally relevant gut taxa.