What does this research mean for the field?

The genome of foot-and-mouth disease virus type A12 contains a 6,912-nucleotide coding region that encodes major viral proteins, which are subsequently processed at specific cleavage sites by viral and cellular proteases. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1985Journal of VirologyOpen Access

Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A12

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Population

Foot-and-mouth disease virus type A12 genome (cloned DNA derived from viral RNA)

Design

Preclinical

Authors

BRBetty H. RobertsonCedars-Sinai Medical Center MGMarvin J. GrubmanPlum Island Animal Disease Center GWGregory N. WeddellBeth Israel Deaconess Hospital

Discussion

Member takes

Implication

Maps FMDV A12 genome structure; leaves open targeted vaccine or antiviral development in livestock.

Structured PICO

Population

Foot-and-mouth disease virus type A12 genome (cloned DNA derived from viral RNA)

Intervention

Nucleotide sequencing and microsequencing of radiolabeled in vivo and in vitro translation products

Outcome

Identification of the coding region for structural and nonstructural polypeptides and cleavage sites

The study maps the coding region and cleavage sites of the foot-and-mouth disease virus type A12 genome, providing foundational knowledge of its viral protein synthesis.

Cite This Study

Robertson et al. (1985) studied this question.

synapsesocial.com/papers/6a18b577d654b1eb0d4ace27 https://doi.org/10.1128/jvi.54.3.651-660.1985

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