Key result
Older age, male gender, smoking, and hypertension were independently associated with a smaller aortoiliac bifurcation distance (cohort mean 26 ± 15 mm), while diabetes was associated with a larger distance.
Why the study?
Are cardiovascular disease risk factors and calcified atherosclerosis associated with aortoiliac bifurcation position?
Cross-Sectional (n=1,711)
Are cardiovascular disease risk factors and calcified atherosclerosis associated with aortoiliac bifurcation position?
Age-related aortoiliac bifurcation descent is associated with specific cardiovascular disease risk factors and markers for aortic disease.
Does not support practice changes; hypothesis-generating for bifurcation position as aortic disease marker.
We investigated associations of cardiovascular disease (CVD) risk factors and calcified atherosclerosis with aortoiliac bifurcation position. The bifurcation position was determined by measuring the distance from the aortoiliac bifurcation to the L5-S1 disk space (or aortoiliac bifurcation distance [AIBD]), using computed tomography scans. The 1711 study participants (51% male) had a mean age of 62 ± 10 years and a mean AIBD of 26 ± 15 mm. In multivariable linear regression, older age, male gender, smoking, hypertension, larger aortic diameter, and smaller lumbar height were each independently associated with a smaller AIBD (more caudal bifurcation position). In contrast, diabetes, elevated triglycerides, and increased pulse pressure were independently associated with a larger AIBD (more cephalad bifurcation position). These findings suggest that age-related bifurcation descent is associated with CVD markers for aortic disease. Future studies should assess whether the bifurcation position is an independent prognosticator for CVD.
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Forbang et al. (2013) conducted a cross-sectional in Cardiovascular disease risk factors and calcified atherosclerosis (n=1,711). Cardiovascular disease risk factors was evaluated on Aortoiliac bifurcation distance (AIBD). Older age, male gender, smoking, and hypertension were independently associated with a smaller aortoiliac bifurcation distance (cohort mean 26 ± 15 mm), while diabetes was associated with a larger distance.
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