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September 1, 1973BloodOpen Access

Lymphoblastic Leukemia with Marked Eosinophilia: A Report of Two Cases

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Authors

GSGary SpitzerIntermountain HealthcareOGO. Margaret GarsonSt Vincent's Hospital

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Implication

Case series reveals reactive eosinophilia mimicking eosinophilic leukemia in acute lymphoblastic leukemia patients, suggesting true acute eosinophilic leukemia is exceptionally rare.

Key Points

  • To determine the relationship and origin of severe eosinophilia occurring in patients with acute lymphoblastic leukemia.
  • Clinical and cytogenetic evaluation of two patients presenting with acute lymphoblastic leukemia and marked eosinophilia that initially prompted a provisional diagnosis of eosinophilic leukemia.
  • Cytogenetic analysis demonstrated that the marked eosinophilia was reactive to the leukemic blast population rather than an intrinsic clonal component of the leukemia.
  • The clinical findings indicate that true acute eosinophilic leukemia occurs even less frequently than widely reported.

Cite This Study

Spitzer et al. (1973) studied this question.

synapsesocial.com/papers/6a18c714b74a086de591b43chttps://doi.org/10.1182/blood.v42.3.377.377
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Hypereosinophilic Syndromes1968 · 492 citations
  2. 2MECHANISM OF EOSINOPHILIA1970 · 213 citations
  3. 3Leukemia-Associated Antigens in the Mixed Leukocyte Culture Test1969 · 65 citations
  4. 4Mechanism of Eosinophilia. III. Suppression of Eosinophilia by Agents Known to Modify Immune Responses1970 · 41 citations
  5. 5Evidence for antigenicity in human tumours with reference to both melanoma and acute leukaemia.1970 · 23 citations