Key result
High initial fitness response to exercise training linked to ~3.9 mL/kg/min less fitness decline at 10 years.
Why the study?
Substantial heterogeneity exists in cardiorespiratory fitness response to exercise training, and its long-term prognostic implication is not well understood.
Does a high cardiorespiratory fitness response to short-term exercise training attenuate long-term fitness decline in overweight and obese adults?
Cohort (n=80)
No
Does a high cardiorespiratory fitness response to short-term exercise training attenuate long-term fitness decline in overweight and obese adults?
Effect estimate: standard β=0.25
Absolute Event Rate: -0.35% vs -4.25%
p-value: p=0.02
Greater cardiorespiratory fitness improvement in response to short-term exercise training is associated with higher fitness levels and attenuated fitness decline 10 years later.
High short-term CRF response may attenuate long-term decline in overweight adults; hypothesis-generating and requires prospective validation.
Background Substantial heterogeneity exists in the cardiorespiratory fitness (CRF) change in response to exercise training, and its long‐term prognostic implication is not well understood. We evaluated the association between the short‐term supervised training‐related changes in CRF and CRF levels 10 years later. Methods and Results STRRIDE (Studies of a Targeted Risk Reduction Intervention Through Defined Exercise) trial participants who were originally randomized to exercise training for 8 months and participated in the 10‐year follow‐up visit were included. CRF levels were measured at baseline, after training (8 months), and at 10‐year follow‐up as peak oxygen uptake ( vo 2 , mL/kg per min) using the maximal treadmill test. Participants were stratified into low, moderate, and high CRF response groups according to the training regimen–specific tertiles of CRF change. The study included 80 participants (age: 52 years; 35% female). At 10‐year follow‐up, the high‐response CRF group had the least decline in CRF compared with the moderate‐ and low‐response CRF groups (−0.35 versus −2.20 and −4.25 mL/kg per minute, respectively; P =0.02). This result was largely related to the differential age‐related changes in peak oxygen pulse across the 3 groups (0.58, −0.23, and −0.86 mL/beat, respectively; P =0.03) with no difference in the peak heart rate change. In adjusted linear regression analysis, high response was significantly associated with greater CRF at follow‐up independent of other baseline characteristics (high versus low [reference] CRF response: standard β=0.25; P =0.004). Conclusions Greater CRF improvement in response to short‐term training is associated with higher CRF levels 10 years later. Lack of CRF improvements in response to short‐term training may identify individuals at risk for exaggerated CRF decline with aging.
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Pandey et al. (2019) conducted a cohort in Overweight/obesity with low baseline fitness (n=80). High cardiorespiratory fitness (CRF) response to short-term exercise training vs. Low and moderate CRF response to short-term exercise training was evaluated on Decline in cardiorespiratory fitness (peak oxygen uptake, mL/kg per min) at 10-year follow-up (standard β=0.25, p=0.02). A high cardiorespiratory fitness response to short-term exercise training was associated with significantly less decline in fitness over 10 years compared to low and moderate responses (-0.35 vs -4.25 and -2.20 mL/kg/min, P=0.02).
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