A facile approach for preparative synthesis of sialyloligosaccharides containing N ‐glycolylneuraminic acid, deaminoneuraminic acid, and two 9‐azido derivatives is described. Synthesis is accomplished by use of 6‐carbon mannose/mannosamine precursors employing an aldolase, CMP‐sialic acid synthetase, and sialyltransferase. Using a combination of five different sialyltransferases and various acceptor substrates, 16 sialosides representing sequences found in glycoproteins and glycolipids were synthesized with typical yields of 60–80%.
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Blixt et al. (2003) studied this question.
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