History of hot flashes and aortic calcification among postmenopausal women
Key result
Among postmenopausal women using hormone therapy, a longer history of reported hot flashes was associated with increased aortic calcification (b = 2.87, P < 0.05).
Why the study?
Is a longer history of hot flashes associated with greater aortic and coronary artery calcification in postmenopausal women?
Population
302 postmenopausal women participating in the Healthy Women Study
Comparison
Longer history of reported hot flashes vs Shorter or no history of hot flashes
Design
Cohort
Follow-up
Up to 14-21 years (initiated 1983, EBT 1997-2004)
Authors
Discussion
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Member takes
Implication
Hot flash duration may flag higher vascular risk in HT users; hypothesis-generating for calcification screening and prospective validation.
Study Design
Type
Cohort (n=302)
Structured PICO
Is a longer history of hot flashes associated with greater aortic and coronary artery calcification in postmenopausal women?
P
Population
302 postmenopausal women participating in the Healthy Women Study
I
Intervention
Longer history of reported hot flashes (assessed at 1, 2, 5, and 8 years postmenopausal)
C
Comparator
Shorter or no history of hot flashes
O
Outcome
Aortic and coronary artery calcification measured by electron beam tomographysurrogate
Main Result
Effect estimate: b = 2.87
p-value: p=<0.05
A longer history of hot flashes is associated with increased aortic calcification in postmenopausal women using hormone therapy, suggesting hot flashes may signal adverse cardiovascular changes.
Cite This Study
Thurston et al. (2010) conducted a cohort in Menopausal hot flashes (n=302). Longer history of reported hot flashes vs. Shorter or no history of hot flashes was evaluated on Aortic and coronary artery calcification (b = 2.87, p=<0.05). Among postmenopausal women using hormone therapy, a longer history of reported hot flashes was associated with increased aortic calcification (b = 2.87, P < 0.05).