Key result
Extracellular Zn2+ inhibited voltage-gated H+ currents in rat alveolar epithelial cells, with apparent potency approximately 10x greater at pH 7 than pH 6, and 100x greater at pH 6 than pH 5.
This preclinical study demonstrates that Zn2+ inhibits voltage-gated proton channels in rat alveolar epithelial cells by competing with protons for external modulatory sites rather than through classical pore block.
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Does not alter clinical practice; challenges classical pore block models of Zn2+ inhibition in proton channels.
Cherny et al. (1999) studied Voltage-gated proton channels in rat alveolar epithelial cells. Zn2+ and other divalent cations was evaluated on Inhibition of voltage-gated H+ currents. Extracellular Zn2+ inhibited voltage-gated H+ currents in rat alveolar epithelial cells, with apparent potency approximately 10x greater at pH 7 than pH 6, and 100x greater at pH 6 than pH 5.
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