The L452R mutation in the receptor-binding domain of the SARS-CoV-2 spike protein is associated with a recent global expansion of numerous independent variants, including the epsilon variant.
Observational
The L452R mutation in the SARS-CoV-2 spike protein is associated with a massive global expansion of variants, including the epsilon variant.
We report that there is a recent global expansion of numerous independent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the receptor-binding domain (RBD) of the spike protein. The massive emergence of L452R variants was first linked to lineage B.1.427/B.1.429 (clade 21C) that has been spreading in California since November and December 2020, originally named CAL.20C and currently variant of interest epsilon.
Tchesnokova et al. (Wed,) conducted a observational in SARS-CoV-2. L452R mutation was evaluated on Expansion of SARS-CoV-2 variants. The L452R mutation in the receptor-binding domain of the SARS-CoV-2 spike protein is associated with a recent global expansion of numerous independent variants, including the epsilon variant.