Key result
In hospitalized patients with pneumonia, elevated troponin levels were associated with a significantly increased risk of 1-year mortality (HR 1.57) compared to those with normal troponin levels.
Why the study?
Pneumonia in hospitalized patients is associated with myocardial injury, but risk factors for this injury and its prognostic value required evaluation.
Do elevated troponin levels predict increased mortality in adult patients hospitalized with pneumonia?
Cohort (n=8,195)
No
Do elevated troponin levels predict increased mortality in adult patients hospitalized with pneumonia?
Effect estimate: HR 1.57 (95% CI 1.42-1.73)
Absolute Event Rate: 47.6% vs 34.6%
p-value: p=<0.001
Elevated troponin levels in patients hospitalized with pneumonia are strongly associated with increased in-hospital and 1-year mortality, suggesting its utility as a risk stratification tool.
Troponin may refine mortality risk assessment in pneumonia; leaves open whether targeted interventions improve outcomes.
Pneumonia in hospitalized patients is associated with myocardial injury. In this study, we evaluated risk factors for myocardial injury in hospitalized patients with pneumonia and its prognostic value. We retrieved all patients who were hospitalized in internal medicine departments in a tertiary medical center between 2008 and 2019 with a diagnosis of pneumonia. From 2008 to 2019 a total of 20,683 adult patients were hospitalized in internal medicine wards in the Sheba Medical Center with a diagnosis of pneumonia, 8195 were tested for troponin levels, and 3207 had elevated levels. Risk factors for elevated troponin levels were age, prior diagnosis of ischemic heart disease, and elevated creatinine level upon admission. The in-hospital mortality and 1-year mortality rate were higher among patients who had elevated troponin levels when using a propensity score-based matched analysis. In conclusion, in hospitalized patients with pneumonia elevated troponin levels have a major impact on prognosis. Hence, troponin levels may be used as another tool of risk stratification for patients hospitalized with pneumonia.
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Efros et al. (2020) conducted a cohort in Pneumonia (n=8,195). Elevated troponin levels vs. Normal troponin levels was evaluated on 1-year mortality (HR 1.57, 95% CI 1.42-1.73, p=<0.001). In hospitalized patients with pneumonia, elevated troponin levels were associated with a significantly increased risk of 1-year mortality (HR 1.57) compared to those with normal troponin levels.
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