Key result
The KCNE1-D85N genetic variant was significantly associated with drug-induced long QT syndrome (adjusted OR 2.24; 95% CI 1.35-3.58; p=0.001).
Why the study?
Candidate genetic variants in cardiac ion channels have been associated with drug-induced long QT syndrome, but limitations of previous studies have hampered clinical utility.
Are genetic variants KCNE1-D85N, KCNE2-I57T, and SCN5A-G615E associated with drug-induced long QT syndrome in patients treated with high-risk QT-prolonging medications?
Case-Control (n=6,083)
Are genetic variants KCNE1-D85N, KCNE2-I57T, and SCN5A-G615E associated with drug-induced long QT syndrome in patients treated with high-risk QT-prolonging medications?
Answers are grounded in this paper and cite their sources.
The genetic variant KCNE1-D85N is significantly associated with an increased risk of drug-induced long QT syndrome in patients taking high-risk QT-prolonging medications.
Aim: Drug-induced long QT syndrome (diLQTS), an adverse effect of many drugs, can lead to sudden cardiac death. Candidate genetic variants in cardiac ion channels have been associated with diLQTS, but several limitations of previous studies hamper clinical utility. Materials & methods: Thus, the purpose of this study was to assess the associations of KCNE1-D85N, KCNE2-I57T and SCN5A-G615E with diLQTS in a large observational case–control study (6,083 self-reported white patients treated with 27 different high-risk QT-prolonging medications; 12.0% with diLQTS). Results: KCNE1-D85N significantly associated with diLQTS (adjusted odds ratio: 2.24 [95% CI: 1.35–3.58]; p = 0.001). Given low minor allele frequencies, the study had insufficient power to analyze KCNE2-I57T and SCN5A-G615E. Conclusion: KCNE1-D85N is a risk factor for diLQTS that should be considered in future clinical practice guidelines.
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Lopez-Medina et al. (2024) conducted a case-control in Drug-induced long QT syndrome (diLQTS) (n=6,083). KCNE1-D85N, KCNE2-I57T and SCN5A-G615E genetic variants was evaluated on Drug-induced long QT syndrome (diLQTS) (OR 2.24, 95% CI 1.35-3.58, p=0.001). The KCNE1-D85N genetic variant was significantly associated with drug-induced long QT syndrome (adjusted OR 2.24; 95% CI 1.35-3.58; p=0.001).
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