Why the study?
What is the frequency and functional significance of long-QT syndrome-related gene mutations in patients with drug-induced long-QT syndrome compared to congenital long-QT syndrome?
What is the frequency and functional significance of long-QT syndrome-related gene mutations in patients with drug-induced long-QT syndrome compared to congenital long-QT syndrome?
Drug-induced long-QT syndrome has a similar genetic mutation rate to congenital long-QT syndrome, suggesting it can be regarded as a latent form of the congenital condition.
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Supports viewing drug-induced LQTS as latent congenital form; leaves open whether mutation status should guide therapy.
Itoh et al. (2009) studied this question.
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