Asymptomatic individuals with exercise-induced premature ventricular complexes exhibited significantly reduced global longitudinal strain compared to controls (-19.6% vs -22.2%), indicating subclinical myocardial dysfunction.
Case-Control (n=141)
Blinded outcome assessment
No
Does the presence of exercise-induced premature ventricular complexes (EI-PVCs) indicate subclinical myocardial dysfunction in asymptomatic individuals without structural heart disease?
Exercise-induced PVCs during the recovery phase in asymptomatic individuals are associated with subclinical myocardial dysfunction and concentric remodeling, suggesting they may serve as early markers of occult cardiac pathology.
Absolute Event Rate: -19.6% vs -22.2%
p-value: p=<0.001
OBJECTIVE: Exercise-induced premature ventricular complexes (EI-PVCs) are key indicators of subclinical cardiac dysfunction and elevated cardiovascular risk. However, their clinical significance and prognostic value remain unclear, particularly in asymptomatic individuals without structural heart disease. This study uses advanced echocardiographic techniques to investigate the relationship between EI-PVCs and subclinical myocardial dysfunction. METHODS: An observational case-control study was conducted with 141 participants (82 controls and 59 cases). Two-dimensional speckle tracking echocardiography (2D-STE) was utilized to assess myocardial function, including global longitudinal strain (GLS). RESULTS: Participants with exerciseinduced PVCs exhibited significantly greater left ventricular mass index (80.1 ± 15.7 vs. 74.3 ± 12.7 g/m²; p = 0.035), markedly reduced global longitudinal strain (-19.6 ± 2.0% vs. - 22.2 ± 1.4%; p < 0.001), and elevated myocardial performance index (0.42 ± 0.07 vs. 0.38 ± 0.06; p = 0.002) compared to controls, despite similar conventional systolic parameters. CONCLUSION: This study highlights EI-PVCs as early markers of subclinical myocardial dysfunction, warranting detailed echocardiographic evaluation in affected individuals. The findings. underscore the need for further research into the burden, morphology, and patterns of EI-PVCs to refine cardiovascular risk stratification and management strategies.
Geneş et al. (Thu,) conducted a case-control in Exercise-induced premature ventricular complexes (EI-PVCs) (n=141). Exercise-induced premature ventricular complexes (EI-PVCs) vs. No PVCs during exercise or recovery was evaluated on Global longitudinal strain (GLS) (p=<0.001). Asymptomatic individuals with exercise-induced premature ventricular complexes exhibited significantly reduced global longitudinal strain compared to controls (-19.6% vs -22.2%), indicating subclinical myocardial dysfunction.