What is the clinical evidence from this study?

Population: Pulmonary Embolism. Intervention: Automated D-Dimer ELISA.

What question did this study set out to answer?

To evaluate the performance of a new automated ELISA for measuring D-dimer levels in patients suspected of pulmonary embolism.

January 1, 1996Thrombosis and Haemostasis

Contribution of a New, Rapid, Individual and Quantitative Automated D-Dimer ELISA to Exclude Pulmonary Embolism

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Key result

The provided text contains only journal masthead and editorial board information, with no clinical study data available for extraction.

Why the study?

Does the VIDAS D-dimer automated ELISA accurately exclude pulmonary embolism in patients suspected of PE?

Key Points

To evaluate the performance of a new automated ELISA for measuring D-dimer levels in patients suspected of pulmonary embolism.
Conducted an initial study with 100 patients to select optimal antibodies.
Prospective evaluation with 195 patients suspected of pulmonary embolism and a cut-off level of 500 ng/ml.
Evaluated sensitivity, specificity, and predictive values during a 6-month follow-up.
VIDAS D-dimer achieved a sensitivity of 100% (95% CI 92-100) for detecting pulmonary embolism.
Specificity was 37.6%, with a negative predictive value of 100% (95% CI 93.3-100).
No patients with D-dimer < 500 ng/ml had new suspicion of venous thromboembolic disease during follow-up.

Structured PICO

Does the VIDAS D-dimer automated ELISA accurately exclude pulmonary embolism in patients suspected of PE?

Population

195 consecutive patients suspected of pulmonary embolism (PE), following an initial study of 100 patients for antibody selection

Intervention

VIDAS D-dimer automated ELISA (cut-off level of 500 ng/ml)

Outcome

Diagnostic performance (sensitivity, specificity, negative predictive value, positive predictive value) for pulmonary embolism and 6-month follow-up for new suspicion of venous thromboembolic diseasesurrogate

The VIDAS D-dimer automated ELISA provides a rapid and highly sensitive method with a 100% negative predictive value to safely exclude pulmonary embolism in clinical practice.

Discussion

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Implication

No extractable clinical data; leaves open whether VIDAS D-dimer safely excludes PE.

Cite This Study

Moerloose et al. (1996) studied Pulmonary Embolism. Automated D-Dimer ELISA was evaluated. The provided text contains only journal masthead and editorial board information, with no clinical study data available for extraction.

synapsesocial.com/papers/6a18e0d7c9d74cf65281fc2a https://doi.org/10.1055/s-0038-1650213

Topics

Pulmonary embolism

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Contribution of a New, Rapid, Individual and Quantitative Automated D-Dimer ELISA to Exclude Pulmonary Embolism

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Contribution of a New, Rapid, Individual and Quantitative Automated D-Dimer ELISA to Exclude Pulmonary Embolism

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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