January 1, 1996Thrombosis and Haemostasis
Contribution of a New, Rapid, Individual and Quantitative Automated D-Dimer ELISA to Exclude Pulmonary Embolism
View Full Paper
Ask AI
Bookmark
Share
Key result
The provided text contains only journal masthead and editorial board information, with no clinical study data available for extraction.
Why the study?
Does the VIDAS D-dimer automated ELISA accurately exclude pulmonary embolism in patients suspected of PE?
Population
195 consecutive patients suspected of pulmonary embolism, following an initial study of 100 patients for…
Design
Cohort
Follow-up
6 months
Authors
Discussion
Loading...
Member takes
Implication
No extractable clinical data; leaves open whether VIDAS D-dimer safely excludes PE.
Key Points
- To evaluate the performance of a new automated ELISA for measuring D-dimer levels in patients suspected of pulmonary embolism.
- Conducted an initial study with 100 patients to select optimal antibodies.
- Prospective evaluation with 195 patients suspected of pulmonary embolism and a cut-off level of 500 ng/ml.
- Evaluated sensitivity, specificity, and predictive values during a 6-month follow-up.
- VIDAS D-dimer achieved a sensitivity of 100% (95% CI 92-100) for detecting pulmonary embolism.
- Specificity was 37.6%, with a negative predictive value of 100% (95% CI 93.3-100).
- No patients with D-dimer < 500 ng/ml had new suspicion of venous thromboembolic disease during follow-up.
Structured PICO
Does the VIDAS D-dimer automated ELISA accurately exclude pulmonary embolism in patients suspected of PE?
P
Population
195 consecutive patients suspected of pulmonary embolism (PE), following an initial study of 100 patients for antibody selection
I
Intervention
VIDAS D-dimer automated ELISA (cut-off level of 500 ng/ml)
O
Outcome
Diagnostic performance (sensitivity, specificity, negative predictive value, positive predictive value) for pulmonary embolism and 6-month follow-up for new suspicion of venous thromboembolic diseasesurrogate
The VIDAS D-dimer automated ELISA provides a rapid and highly sensitive method with a 100% negative predictive value to safely exclude pulmonary embolism in clinical practice.
Cite This Study
Moerloose et al. (1996) studied Pulmonary Embolism. Automated D-Dimer ELISA was evaluated. The provided text contains only journal masthead and editorial board information, with no clinical study data available for extraction.
Topics
View Full Paper
Ask AI
Bookmark
Share