What does this research mean for the field?

Rat apolipoprotein A-I is initially synthesized as a larger precursor protein (preapoA-I) that undergoes cotranslational cleavage by microsomal membranes to form the mature plasma protein. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1981Biochemistry

Characterization, cell-free synthesis and processing of apolipoprotein A-I of rat high-density lipoproteins

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Population

Rat high-density lipoproteins, rat liver poly(A) RNA, and dog pancreatic microsomal membranes

Design

Preclinical

Authors

MLMing-Huey Lin-SuBaylor College of Medicine YLYen-Chiu Lin-LeeThe University of Texas MD Anderson Cancer Center WBWilliam A. BradleyGeorgia Institute of Technology

Discussion

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Implication

Hypothesis-generating for apoA-I biosynthesis; leaves open in vivo relevance and clinical translation.

Structured PICO

Population

Rat high-density lipoproteins, rat liver poly(A) RNA, and dog pancreatic microsomal membranes

Intervention

In vitro translation of rat liver poly(A) RNA in cell-free systems with and without dog pancreatic microsomal membranes

Outcome

Synthesis and processing of apolipoprotein A-I precursor (preapoA-I)

This basic science study identifies a putative precursor to rat apoA-I (preapoA-I) and demonstrates its cell-free processing to the mature plasma protein.

Cite This Study

Lin-Su et al. (1981) studied this question.

synapsesocial.com/papers/6a18e9268dcaf40f45cfe6c9 https://doi.org/10.1021/bi00512a017

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Characterization, cell-free synthesis and processing of apolipoprotein A-I of rat high-density lipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization, cell-free synthesis and processing of apolipoprotein A-I of rat high-density lipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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