Key result
Thoracic epidural anesthesia completely abolished the positive inotropic response to acute pulmonary hypertension and significantly lowered cardiac output compared to untreated controls.
Why the study?
Does thoracic epidural anesthesia impair right ventricular contractility and ventriculo-vascular coupling during acute pulmonary hypertension in a pig model?
Population
14 pigs (mean weight, 35 +/- 2 kg) in an established model of acute pulmonary hypertension
Comparison
Thoracic epidural anesthesia followed by… vs Placebo/control followed by induction of…
Design
Preclinical, Placebo-controlled
Follow-up
Acute (during hypoxia-induced pulmonary hypertension)
Authors
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Thoracic epidural anesthesia may impair right ventricular compensation in acute pulmonary hypertension; leaves open clinical relevance pending human studies.
Does thoracic epidural anesthesia impair right ventricular contractility and ventriculo-vascular coupling during acute pulmonary hypertension in a pig model?
Thoracic epidural anesthesia impairs the right ventricle's compensatory inotropic response to acute pulmonary hypertension, leading to deteriorated hemodynamics in a preclinical model.
Rex et al. (2006) studied Acute pulmonary hypertension (n=14). Thoracic epidural anesthesia vs. Placebo was evaluated on Right ventricular contractility and cardiac output. Thoracic epidural anesthesia completely abolished the positive inotropic response to acute pulmonary hypertension and significantly lowered cardiac output compared to untreated controls.
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