Key result
Alcohol septal ablation and surgical myectomy had similar unadjusted rates of all-cause mortality, but after adjustment, ASA was associated with lower mortality (OR 0.28; 95% CI 0.16-0.46).
Why the study?
Does alcohol septal ablation reduce all-cause mortality and sudden cardiac death compared to surgical myectomy in patients with obstructive hypertrophic cardiomyopathy?
Population
4,094 patients with obstructive hypertrophic cardiomyopathy from 27 studies
Comparison
Alcohol septal ablation (ASA) vs Surgical myectomy
Design
Meta-analysis
Follow-up
Median 51 patient-years for ASA versus 1266 patient-years…
Authors
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Adjusted observational data suggest lower mortality with ASA but should not change practice; leaves open need for RCTs in obstructive HCM.
Meta-Analysis (n=4,094)
Does alcohol septal ablation reduce all-cause mortality and sudden cardiac death compared to surgical myectomy in patients with obstructive hypertrophic cardiomyopathy?
Effect estimate: OR 0.28 (95% CI 0.16 to 0.46)
Absolute Event Rate: 0.021% vs 0.018%
p-value: p=0.37
In a meta-analysis of observational studies, alcohol septal ablation was associated with lower adjusted odds of all-cause mortality and sudden cardiac death compared to surgical myectomy in patients with obstructive hypertrophic cardiomyopathy.
Leonardi et al. (2010) conducted a meta-analysis in obstructive hypertrophic cardiomyopathy (n=4,094). Alcohol septal ablation vs. Surgical myectomy was evaluated on All-cause mortality (OR 0.28, 95% CI 0.16 to 0.46, p=0.37). Alcohol septal ablation and surgical myectomy had similar unadjusted rates of all-cause mortality, but after adjustment, ASA was associated with lower mortality (OR 0.28; 95% CI 0.16-0.46).
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