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July 1, 2005International Journal of Cardiovascular Interventions

Intracardiac echocardiography guidance during percutaneous transluminal septal myocardial ablation in patients with obstructive hypertrophic cardiomyopathy

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Why the study?

Does intracardiac echocardiography guidance during percutaneous transluminal septal myocardial ablation reduce gradient in symptomatic HOCM patients?

Population

9 symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients with drug-refractory symptoms

Design

Case_series

Key result

Intracardiac echocardiography-guided percutaneous transluminal septal myocardial ablation safely reduced the gradient from 78.9 mmHg to 7.8 mmHg (p<0.0001) in symptomatic HOCM patients.

Authors

CPChiara PedoneMVM VijayakumarJLJourgen M. L. Ligthart

Discussion

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Overview

May support ICE-guided PTSMA in select HOCM cases; leaves open prospective RCTs for confirmation and practice change.

Study Design

Type

Observational (n=9)

Structured PICO

Does intracardiac echocardiography guidance during percutaneous transluminal septal myocardial ablation reduce gradient in symptomatic HOCM patients?

P
Population
9 symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients with drug-refractory symptoms
I
Intervention
Percutaneous transluminal septal myocardial ablation (PTSMA) guided by intracardiac echocardiography (ICE)
O
Outcome
Reduction in gradient and procedural safety/imaging qualitysurrogate

Main Result

Absolute Event Rate: 7.8% vs 78.9%

p-value: p=<0.0001

Intracardiac echocardiography guidance during percutaneous transluminal septal myocardial ablation in HOCM patients is safe and effectively reduces the left ventricular outflow tract gradient.

Limitations

  • initial experience

Cite This Study

Pedone et al. (2005) conducted an observational in hypertrophic obstructive cardiomyopathy (HOCM) (n=9). Intracardiac echocardiography (ICE) guided percutaneous transluminal septal myocardial ablation (PTSMA) was evaluated on Gradient reduction (p=<0.0001). Intracardiac echocardiography-guided percutaneous transluminal septal myocardial ablation safely reduced the gradient from 78.9 mmHg to 7.8 mmHg (p<0.0001) in symptomatic HOCM patients.

synapsesocial.com/papers/6a1904e00666c170ed4f6f31https://doi.org/10.1080/14628840500280575
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