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March 1, 2002Cardiology in Review

Role of Controlled Septal Infarct in Hypertrophic Obstructive Cardiomyopathy

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Key result

Nonsurgical septal reduction therapy (alcohol septal ablation) improves left ventricular outflow tract obstruction and symptoms in hypertrophic obstructive cardiomyopathy at 1 year follow-up.

Why the study?

Does nonsurgical septal reduction therapy (alcohol septal ablation) improve symptoms and left ventricular outflow tract obstruction in patients with hypertrophic obstructive cardiomyopathy?

Population

Patients with hypertrophic obstructive cardiomyopathy

Design

Review

Follow-up

1 year

Authors

CNChristopher D. NielsenMedical University of South CarolinaWSWilliam H. SpencerDiane and Bruce Halle Foundation

Discussion

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Implication

May support alcohol septal ablation in select HOCM; leaves open need for randomized trials versus myectomy.

Structured PICO

Does nonsurgical septal reduction therapy (alcohol septal ablation) improve symptoms and left ventricular outflow tract obstruction in patients with hypertrophic obstructive cardiomyopathy?

P
Population
Patients with hypertrophic obstructive cardiomyopathy
I
Intervention
Nonsurgical septal reduction therapy (alcohol septal ablation)

Nonsurgical septal reduction therapy (alcohol septal ablation) is an effective percutaneous intervention for improving gradients and symptoms in hypertrophic obstructive cardiomyopathy, with complete heart block as the most common complication.

Cite This Study

Nielsen et al. (2002) conducted a review in Hypertrophic obstructive cardiomyopathy. Nonsurgical septal reduction therapy (alcohol septal ablation) was evaluated. Nonsurgical septal reduction therapy (alcohol septal ablation) improves left ventricular outflow tract obstruction and symptoms in hypertrophic obstructive cardiomyopathy at 1 year follow-up.

synapsesocial.com/papers/6a1904e00666c170ed4f6f35https://doi.org/10.1097/00045415-200203000-00009

Topics

Hypertrophic cardiomyopathyAF ablation outcomes
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy: long term follow up of the first series of 25 patients2000 · 165 citations
  2. 2Regression of Left Ventricular Hypertrophy After Nonsurgical Septal Reduction Therapy for Hypertrophic Obstructive Cardiomyopathy2001 · 162 citations
  3. 3Long-term results of left ventricular myotomy and myectomy for obstructive hypertrophic cardiomyopathy1996 · 218 citations
  4. 4Assessment of Permanent Dual-Chamber Pacing as a Treatment for Drug-Refractory Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy1999 · 497 citations
  5. 5Long-term results of dual-chamber (DDD) pacing in obstructive hypertrophic cardiomyopathy. Evidence for progressive symptomatic and hemodynamic improvement and reduction of left ventricular hypertrophy.1994 · 384 citations