Key result
Propofol prevented Angiotensin II-induced cardiomyocyte hypertrophy in vitro by interfering with reactive oxygen species generation, MEK/ERK signaling, and NF-kappaB activation.
Authors
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Should not change clinical practice; leaves open whether propofol attenuates hypertrophy in vivo.
Zou et al. (2008) studied Cardiomyocyte hypertrophy. Propofol vs. Angiotensin II alone was evaluated on Angiotensin II-induced cardiomyocyte hypertrophy and ROS formation. Propofol prevented Angiotensin II-induced cardiomyocyte hypertrophy in vitro by interfering with reactive oxygen species generation, MEK/ERK signaling, and NF-kappaB activation.
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