Christopher K. Daugherty, Donald M. Banik, Linda Janish, Mark J. Ratain, Quantitative Analysis of Ethical Issues in Phase I Trials: A Survey Interview Study of 144 Advanced Cancer Patients, IRB: Ethics & Human Research, Vol. 22, No. 3 (May - Jun., 2000), pp. 6-14
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Daugherty et al. (2000) studied this question.