Key result
A genetic predisposition for familial dilated cardiomyopathy may act as a risk factor for anthracycline-induced cardiotoxicity, as demonstrated in 2 patients who developed severe DCM.
Why the study?
Does a genetic predisposition for familial dilated cardiomyopathy increase the risk of anthracycline-induced cardiotoxicity?
Case Report (n=2)
No
Does a genetic predisposition for familial dilated cardiomyopathy increase the risk of anthracycline-induced cardiotoxicity?
No takes yet. Share an insight, caveat, or question.
A family history of dilated cardiomyopathy may act as a genetic risk factor that interacts with anthracycline therapy to elicit early-onset or severe cardiotoxicity.
Berg et al. (2010) conducted a case report in Anthracycline-induced cardiotoxicity and familial dilated cardiomyopathy (n=2). Anthracyclines (daunorubicin, doxorubicin) was evaluated on Development of dilated cardiomyopathy. A genetic predisposition for familial dilated cardiomyopathy may act as a risk factor for anthracycline-induced cardiotoxicity, as demonstrated in 2 patients who developed severe DCM.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: