Key result
CHEST-A risk score yields a 0.84 C-statistic for predicting three-month MACE in suspected NSTE-ACS.
Why the study?
To investigate a new risk score for acute chest pain with suspected non-ST-segment elevation acute coronary syndrome.
Does the CHEST-A risk score accurately predict major adverse cardiac events in adult patients presenting to the emergency department with suspected NSTE-ACS?
Cohort (n=1,568)
No
Does the CHEST-A risk score accurately predict major adverse cardiac events in adult patients presenting to the emergency department with suspected NSTE-ACS?
Effect estimate: C-statistic 0.84 (95% CI 0.81-0.86)
p-value: p=<0.001
The newly developed CHEST-A risk score, which incorporates high-sensitivity troponin I, provides excellent discrimination for predicting 3-month major adverse cardiac events and can aid in the triage of emergency department patients with suspected NSTE-ACS.
May support ED triage in suspected NSTE-ACS; leaves open external validation before clinical use.
OBJECTIVE: To investigate a new risk score for acute chest pain with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: Patients who suffered from Chest pain and suspected NSTE-ACS were enrolled as subjects. Predictor variables had been analyzed, and a bootstrap technique was used to evaluate the internal validity of the model, and external validation had been assessed for a prospective cohort study. RESULTS: Thousand five hundred and sixty-eight patients had been included in this study. Six predictor variables were found to be significant and were used to develop the model. The C-statistic of the model was 0.83, and internal validation revealed the stability of the model and the absence of over-optimism. Patients were given different triage recommendations, and the risk score was prospectively validated. CONCLUSIONS: A risk score may be a suitable method for assessing the risk of major adverse cardiac events and aiding patient triage in emergency departments among patients with suspected NSTE-ACS.
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Ma et al. (2021) conducted a cohort in Acute chest pain with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) (n=1,568). CHEST-A risk score was evaluated on Major adverse cardiac events (MACE) within 3 months (C-statistic 0.84, 95% CI 0.81-0.86, p=<0.001). The CHEST-A risk score demonstrated excellent discrimination for predicting major adverse cardiac events within three months in patients with suspected NSTE-ACS, with a C-statistic of 0.84.
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