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Normal oxygen delivery is essential for vertebrate homeostasis. Adaptation to changes in oxygen supply involves complex but specific changes in gene expression. This review summarizes recent information on the molecular anatomy and physiology of the first hypoxia-inducible transcription factor (HIF-1) discovered in mammals. Identifications of HIF-1 provides an important tool for investigating oxygen-sensing and signaling mechanisms.
Gassmann et al. (Wed,) studied this question.