Key result
Serum TNF alpha and IL-6 concentrations were independently associated with ECG abnormalities, each increasing by approximately 50% (P<0.05 for TNF alpha, P<0.1 for IL-6).
Why the study?
Are serum concentrations of TNF alpha and IL-6 associated with cardiovascular risk factors and prevalent coronary heart disease in men aged 50 to 69 years?
Population
198 men aged 50 to 69 years from a random population sample drawn from south London
Design
Cross-sectional
Authors
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TNF-α/IL-6 associations with ECG abnormalities are hypothesis-generating; extends CRP observations to upstream cytokines without causal inference.
Cross-Sectional (n=198)
Are serum concentrations of TNF alpha and IL-6 associated with cardiovascular risk factors and prevalent coronary heart disease in men aged 50 to 69 years?
p-value: p=<0.05
Serum concentrations of TNF alpha and IL-6 are associated with cardiovascular risk factors and prevalent coronary heart disease, suggesting they may mediate the phenomena associated with C-reactive protein.
Mendall et al. (1997) conducted a cross-sectional in Cardiovascular risk factors and prevalent coronary heart disease (n=198). Serum cytokine concentrations (TNF alpha and IL-6) was evaluated on Association of serum TNF alpha and IL-6 with cardiovascular risk factors and prevalent coronary heart disease (p=<0.05). Serum TNF alpha and IL-6 concentrations were independently associated with ECG abnormalities, each increasing by approximately 50% (P<0.05 for TNF alpha, P<0.1 for IL-6).
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