Serum TNF alpha and IL-6 concentrations were independently associated with ECG abnormalities, each increasing by approximately 50% (P<0.05 for TNF alpha, P<0.1 for IL-6).
Cross-Sectional (n=198)
Are serum concentrations of TNF alpha and IL-6 associated with cardiovascular risk factors and prevalent coronary heart disease in men aged 50 to 69 years?
Serum concentrations of TNF alpha and IL-6 are associated with cardiovascular risk factors and prevalent coronary heart disease, suggesting they may mediate the phenomena associated with C-reactive protein.
p-value: p=<0.05
OBJECTIVE: To determine whether serum concentrations of the cytokines tumour necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6), which regulate C reactive protein, are associated with cardiovascular risk factors and prevalent coronary heart disease. DESIGN: A population based cross sectional study. SUBJECTS AND METHODS: 198 men aged 50 to 69 years were part of a random population sample drawn from south London. Serum cytokine and C reactive protein concentrations were determined by enzyme linked immunosorbent assay. The presence of coronary heart disease was determined by Rose angina questionnaire and Minnesota coded electrocardiogram. RESULTS: Serum TNF alpha concentrations were positively related to body mass index and Helicobacter pylori infection, but inversely related to alcohol consumption. IL-6 concentrations were positively associated with smoking, symptoms of chronic bronchitis, age, and father having a manual occupation. TNF alpha was associated with increased IL-6 and triglycerides, and reduced high density lipoprotein cholesterol. IL-6 was associated with raised fibrinogen, sialic acid, and triglycerides. ECG abnormalities were independently associated with increases in IL-6 and TNF alpha, each by approximately 50% (P < 0.05 for TNF alpha, P < 0.1 for IL-6). The corresponding increases in men with an abnormal ECG or symptomatic coronary heart disease were 28% for TNF alpha and 36% for IL-6 (P = 0.14 for TNF alpha and P < 0.05 for IL-6). CONCLUSIONS: This study confirms that many of the phenomena with which C reactive protein is associated, are also associated with serum levels of cytokine, which may be the mechanism.
Mendall et al. (Mon,) conducted a cross-sectional in Cardiovascular risk factors and prevalent coronary heart disease (n=198). Serum cytokine concentrations (TNF alpha and IL-6) was evaluated on Association of serum TNF alpha and IL-6 with cardiovascular risk factors and prevalent coronary heart disease (p=<0.05). Serum TNF alpha and IL-6 concentrations were independently associated with ECG abnormalities, each increasing by approximately 50% (P<0.05 for TNF alpha, P<0.1 for IL-6).