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January 1, 2026Open Access

Analysis of aggregates in naked mRNA and mRNA extracted from lipid nanoparticles in a mRNA vaccine against COVID-19

Renata Santos Natália Souza Ana Andrade Talita França Raysa Souza Ana Bergamo Renato Carvalho Karolyne Ruibal Patrícia Neves Ana Bom

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Key Points

The aim is to analyze aggregates in naked mRNA versus mRNA from lipid nanoparticles in a COVID-19 vaccine.
Analyze components of mRNA before and after extraction from lipid nanoparticles.
Examine aggregate formation in different types of mRNA samples.
Present findings at the International Symposium on Immunobiologicals.
Identification of differences in aggregate presence between naked mRNA and lipid nanoparticle-extracted mRNA.
Insights into mRNA stability and interaction with lipid nanoparticles for better vaccine efficacy.

Implication

Analyzes aggregates in mRNA vaccines, suggesting insights for vaccine development.

Abstract

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Cite This Study

Santos et al. (2026) studied this question.

synapsesocial.com/papers/6a192c0ffab5b468c44150a7 https://doi.org/10.35259/isi.2026_76325

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